Category Archives: Development lab

Findings at this stage often grab the most headlines – a new drug tested in mice, or a new marker found in the blood of patients. These stories inspire real hope, because they are applicable to our lives and could be a step towards new treatments being available to patients sooner.

We share this excitement – well designed and thorough studies at this stage can provide strong evidence for a new treatment or intervention. But we still urge caution.

Was the study done in animals or people? How many people took part? Did they see a big effect? Do the findings back up previous evidence?

These are the questions we ask ourselves when new stories are featured in the press. Positive findings must be able to be repeated, to show that they weren’t just due to chance. As the supporting evidence builds, so do our confidence levels.

New anti-inflammatory molecule could hold promise for Alzheimer’s

Research led by scientists at Trinity College Dublin has identified a protein called NLRP3 which plays a role in inflammatory diseases such as multiple sclerosis and cryopyrin-associated periodic syndrome (CAPS). The researchers have developed a compound that can block the action of NLRP3 and shown that it can reduce the severity of disease in a mouse showing features of human multiple sclerosis. The research team suggests that the compound could have benefits across a wide range of immune disorders, as well as against diseases like Alzheimer’s and Parkinson’s.

Playing American football in youth linked to memory problems in adulthood

Research in the US has found that former National Football League (NFL) players who started playing American tackle football before the age of 12 may have worse memory in later life, compared to those who began playing the sport later in their youth. The study is published on Wednesday 28 January in the journal Neurology online.